Way late to reply, but in case anyone sees what you posted, hopefully this will correct it.
In short, yes, it certainly will work with a Mac. Or Linux. Or ANYTHING that supports standard USB operation. It will appear to your computer as if it were a USB flash drive.
Plus, if you put Rockbox on it, you can use high capacity MicroSDHC cards with it (otherwise, you’re limited to 2GB MicroSD cards, which is still quite useful).